Other than winter time when our water clears up, our waters are generally on the dirty side. Very thin profiles can work great in the winter and select times of the year. Too much profile and they can be difficult to cast. With our water, we want some profile so our fish can see the fly easily. If bonefish flies tend to run thinner than your pinky width when in the water, Redfish Flies around here would be a little bigger than your thumb width when they are in the water. Flies that are similar in size and shape to our mudminnows, shrimp, and small crabs that we have in our waters are what we are going for or a hair bigger.
Color? Well if it aint Chartreuse, it aint no use! Just Kidding! Chartreuse is a great color for redfish flies along with darker shades like Black and Purple. They work well in our dirty water. A good generalization is the clearer the water, the lighter the color, and the darker the water, the darker the fly. These are not hard and fast rules but this will serve you well.
Weed guards are very important. You want your flies to not get stuck in grass and oysters. I use 20-25lb hard Mason.
Size of our flies tend to run from 2-5 inches in length with a short shank 1/0 to 2/0 hook.
These are generalizations and are by no means Rules. The most important part of the redfish equation is Presentation. So the best fly is the one you believe in. Good luck out there.